2020/01

Short reviews, 005⁠–009 | DOI: 10.53260/EGO.202012

Premature Ovarian Insufficiency

Stavroula A. Paschou, Areti Augoulea, Nikos Syggelos, Irene Lambrinoudaki

Abnormal vascular architecture at the placental-maternal interface in preeclampsia

Original articles | P.042⁠–046 | DOI: doi.org/10.53260/EGO.202018 | Citation

Abstract

Background and purpose: The aim of this study was to characterize the vascular architecture in the placental bed in pregnancies complicated by preeclampsia and in normal pregnancies.|
Methods: Vessel numbers and cross-section area density in 11 preeclamptic placental beds were compared with 10 normal placental beds using computer-assisted image analysis of whole-slide CD31-immunolabeled sections.|
Results: The total surface occupied by vessels was significantly reduced in preeclamptic placental beds compared with controls beds. However, the number of vessels/section and average surface were similar in all cases. Vessel size distribution differed between the two groups: more smaller vessels were found in preeclamptic placental beds.|
Conclusions: Using a whole slide scanning and computer-assisted analysis method, we demonstrated a different morphological architecture of vessels in the placental beds of preeclamptic patients which might reflect the previously reported findings of insufficient trophoblast invasion and incomplete vascular remodeling.

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Keywords: , ,

Citation: Tack J.,Munaut C.,Blacher S.,Noël A.,Nisolle M.,Chantraine F., Abnormal vascular architecture at the placental-maternal interface in preeclampsia, EGO European Gynecology and Obstetrics (2020); 2020/01:042⁠–046 doi: 10.53260/EGO.202018

Published: January 1, 2020

ISSUE 2020/01

Short reviews, 005⁠–009 | DOI: 10.53260/EGO.202012

Premature Ovarian Insufficiency

Stavroula A. Paschou, Areti Augoulea, Nikos Syggelos, Irene Lambrinoudaki