2020/04

Locally advanced cervical cancer: a descriptive analysis of 20 patients with a visceral recurrence

Original articles | P.255⁠–261 | DOI: doi.org/10.53260/EGO.2020411 | Citation

Abstract

Purpose: To perform a descriptive analysis of patients with locally advanced cervical cancer (LACC) who developed a visceral recurrence, and to identify factors that may favor this atypical aggressive progression.
Patients and methods: The data from twenty patients with LACC and visceral recurrence were retrospectively reviewed.
Results: The majority of the patients (85%) developed a recurrence within 2 years of their primary therapy. All died from their cancer, with a median survival of 28.7 months (range 13.4 - 35.9 months). None of the characteristics related to the patient, the tumor, or the treatment were associated with visceral recurrence (p> 0.05). The International Federation of Gynaecology and Obstetrics (FIGO) 2009 classification only plays a partial role in predicting the risk of recurrence. On the other hand, the FIGO 2018 version appears to be more discriminating by taking the lymph node status into account.
Conclusion: LACC is a heterogeneous group of diseases with a wide range of outcomes. No clear prognostic factors are associated with visceral progression. Other variables – probably linked to the molecular changes within the tumor itself – may constitute a means to stratify the development risk once identified and standardized, but may also be useful for targeted therapies.

PDF

Keywords: , , , , ,

Citation: Verjans J.,Kridelka F.,de Cuypere M.,Gennigens C., Locally advanced cervical cancer: a descriptive analysis of 20 patients with a visceral recurrence, EGO European Gynecology and Obstetrics (2020); 2020/04:255⁠–261 doi: 10.53260/EGO.2020411

Published: October 1, 2020

ISSUE 2020/04