Abstract
Purpose: This study was conducted to test the luteinizing hormone/anti-Müllerian hormone (LH/AMH) ratio as a possible new predictive factor for outcomes after controlled ovarian hyperstimulation (COH) in women undergoing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) treatment.
Methods: This retrospective cohort study included 164 women submitted to their first IVF/ICSI treatment.
Results: Pregnancy and live birth rates were 21.5% and 18.6%, respectively. In a generalized linear model for the prediction of oocyte quantity after COH, age (odds ratio, OR, 0.98, 95% confidence interval, CI, 0.97;0.99), smoking (OR 0.83, 95%CI 0.68;0.99), AMH serum levels (OR 1.06, 95%CI 1.03;1.09) and a higher LH/AMH ratio (OR 0.97, 95%CI 0.96;0.98) were associated with oocyte quantity. For both ongoing pregnancy and live birth rates, only age was found to be predictive (OR 0.92, 95%CI 0.86;0.97, and 0.87, 95%CI 0.78;0.96; respectively).
Conclusion: The LH/AMH ratio is a new predictive parameter for oocyte quantity after COH. However, for the clinically more relevant outcome parameters of ongoing pregnancy and live birth, only patient age was significantly predictive.
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Copyright (c) 2019 Julian Marschalek, Kazem Nouri, Franz Xaver Singhartinger, Marlene Hager, Marie-Louise Marschalek, Katharina Walch, Johannes Ott