Abstract
Holoprosencephaly (HPE) is a congenital malformation of the brain and face due to incomplete cleavage of the prosencephalon. It affects one in 15,000 to 16,000 births. A 37-year-old patient with a medical history of type 2 diabetes under insulin treatment, and an infection with SARS-CoV-2 at 17 weeks of gestation during this pregnancy was referred to us at 21 weeks gestation following the discovery at the second-trimester ultrasound of an alobar HPE. A multidisciplinary meeting concluded that a termination of pregnancy was necessary given the poor neurological prognosis. Although, HPE is a rare congenital brain malformation. Prenatal ultrasound is the preferred diagnostic tool for detecting the condition and determining the need for pregnancy termination
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