Abstract
Tuberculosis remains a global public health threat, with pulmonary presentation being the most common. Thus, extra-pulmonary sites can often go unrecognized in non-endemic regions. As global migration rises, urogenital tuberculosis is a condition to be recognized, especially in urogynecology populations. A post-menopausal woman presented to the urogynecology office with lower urinary tract symptoms. Routine urinalysis revealed persistent sterile pyuria and microhematuria. A computed-tomographic urogram demonstrated features suggestive of a chronic infectious inflammatory process. The patient’s urine was then tested for acid fast bacilli which was positive, and then referred to the infectious disease and renal specialists for co-management. She was treated with anti-tubercular drugs for a total of nine months, after which she made a complete recovery. Urogynecology clinics are environments where urine sample collection and testing are almost ubiquitous. Hence, sterile pyuria, a potential indicator for extra-pulmonary urogenital tuberculosis, should not be overlooked when identified, especially in patients from tuberculosis endemic countries.
References
Shah KK, Pritt BS, Alexander MP. Histopathologic review of granulomatous inflammation. J Clin Tuberc other Mycobact Dis. 2017;7:1-12.
Furin J, Cox H, Pai M. Tuberculosis. Lancet. 2019;393(10181):1642-1656.
Lawn SD, Zumla AI. Tuberculosis. Lancet. 2011;378(9785):57-72.
World Health Organization. Global Tuberculosis Report 2018. Geneva: World Health Organization: https://apps.who.int/iris/handle/10665/274453
Gow J. Genitourinary Tuberculosis. Campbell’s Urology, 7th WB Saunders Company, Philadelphia, Pennsylvania. 1998.
Christensen WI. Genitourinary tuberculosis: review of 102 cases. Medicine (Baltimore). 1974;53(5):377-390.
Muneer A, Macrae B, Krishnamoorthy S, Zumla A. Urogenital tuberculosis — epidemiology, pathogenesis and clinical features. Nat Rev Urol. 2019;16(10):573-598.
Carl P, Stark L. Indications for surgical management of genitourinary tuberculosis. World J Surg. 1997;21(5):505-510.
Figueiredo AA, Lucon AM. Urogenital tuberculosis: update and review of 8961 cases from the world literature. Rev Urol. 2008;10(3):207-217.
Kulchavenya E, Cherednichenko A. Urogenital tuberculosis, the cause of ineffective antibacterial therapy for urinary tract infections. Ther Adv Urol. 2018;10(3):95-101.
Ryan ET, Hill DR, Solomon T, Aronson N, Endy PT. Hunter’s Tropical Medicine and Emerging Infectious Disease. 10th Elsevier; 2020. https://doi.org/10.1016/C2016-0-01879-X
Figueiredo AA, Lucon AM, Srougi M. Urogenital Tuberculosis. Microbiol Spectr. 2017;5(1).
Chandran S, Rahman A, Norris JM, Tiberi S, Kunst H. Diagnostic pitfalls of urogenital tuberculosis. Trop Med Int Heal. 2021;26(7):753-759.
Chugh KS, Datta BN, Singhal PC, Jain SK, Sakhuja V, Dash SC. Pattern of renal amyloidosis in Indian patients. Postgrad Med J. 1981;57(663):31-35.
Chapagain A, Dobbie H, Sheaff M, Yaqoob MM. Presentation, diagnosis, and treatment outcome of tuberculous-mediated tubulointerstitial nephritis. Kidney Int. 2011;79(6):671-677.
Eastwood JB, Corbishley CM, Grange JM. Tuberculosis and the kidney. J Am Soc Nephrol. 2001;12(6):1307-1314.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Kazila Bhutia, Ng Ding Yi, Tanaka Dune, Han How Chuan

