Abstract
Fertility preservation (FP) techniques should be performed ideally before starting gender-affirming hormone treatment (GAHT) but, in some cases, testosterone treatment may have already initiated. Oocyte and embryo cryopreservation are the established methods for FP, and discontinuing the hormonal treatment is advised before performing the oocyte cryopreservation process. We report a case of ovarian controlled hyperstimulation for FP after cessation of testosterone for 4 months in a young patient with more than 5 years in GAHT. Menses were reassumed and a good response was achieved with 10 mature oocytes cryopreserved. It is imperative to provide comprehensive FP counselling before initiating GAHT. Stopping testosterone therapy has shown to be safe and efficient, although it can cause important dysphoria in some people. Few studies have shown reproductive results without stopping testosterone therapy but the impact on embryonic development, aneuploidy, and the long-term health of the offspring remains unknown.
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